Presidential candidates Hillary Rodham Clinton, Barack Obama and John McCain called for the release of political prisoners in Cuba following Fidel Castro's resignation Tuesday.

All three candidates also said the United States should look for ways to encourage Democratic reforms in Cuba.

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"Cuba's future should be determined by the Cuban people and not by an anti-democratic successor regime," Obama said. "The prompt release of all prisoners of conscience wrongly jailed for standing up for the basic freedoms too long denied to the Cuban people would mark an important break with the past. It's time for these heroes to be released."